Cognitive
Noopept
10mg
$69
Dipeptide nootropic that enhances memory consolidation, upregulates NGF and BDNF expression, and provides neuroprotection against oxidative and excitotoxic damage.
- Tested by Freedom Diagnostics — independent US lab
- COA published with every lot
- Shipped from the US
For in-vitro research use only. Not for human or veterinary consumption, diagnostic, or therapeutic use.
Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is a synthetic dipeptide nootropic developed in Russia and reported to be 1,000 times more potent than piracetam by weight. It is a prodrug for cycloprolylglycine, an endogenous neuropeptide that modulates AMPA receptors. Noopept upregulates NGF and BDNF expression, enhances alpha and beta brain wave activity, and provides neuroprotection against glutamate excitotoxicity and oxidative stress.
Noopept is hydrolyzed to cycloprolylglycine, which potentiates AMPA receptor conductance and enhances long-term potentiation in hippocampal circuits. It increases NGF and BDNF mRNA expression in the hippocampus and cortex, supporting neuronal maintenance and synaptic plasticity. It also inhibits acetylcholinesterase mildly, raises acetylcholine availability, and reduces lipid peroxidation.
- Molecular Formula
- C₁₇H₂₂N₂O₄
- Molecular Weight
- 318.4 g/mol
- Form
- Lyophilized powder
- Solubility
- Soluble in water and ethanol
- Dosage Range
- 10–30mg daily (research context)
- Plasma Half-Life
- ~30–60 minutes
- Bioavailability
- ~99% intranasal; ~100% sublingual
Certificate of analysis
Independent third-party report for the lot you receive — identity and purity. Available on request with your order; we'll email it back the same business day.
Cold-chain when required
Temperature-sensitive peptides ship with insulation and coolant. Store as indicated on the vial. Stability notes included with the order.
For research only
Sold for in-vitro research and laboratory use. Not for human or veterinary consumption. We don't advise on protocols or dosing.
- [01]
Noopept stimulates NGF and BDNF expression in rat hippocampus
Ostrovskaya R.U. et al. · Bulletin of Experimental Biology and Medicine · 2008
Noopept significantly increased NGF and BDNF mRNA levels in rat hippocampus and cortex after 28 days of administration.
- [02]
Noopept and cognitive function in patients with mild cognitive impairment
Neznamov G.G. & Teleshova E.S. · Neuroscience and Behavioral Physiology · 2009
Noopept improved memory, attention, and cognitive performance in a randomized controlled trial of patients with mild cognitive impairment.
- [03]
Neuroprotective effects of Noopept against glutamate excitotoxicity
Gudasheva T.A. et al. · European Journal of Pharmacology · 1996
Noopept protected cortical neurons against glutamate-induced excitotoxicity and reduced lipid peroxidation markers in neuronal cultures.
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