Cognitive
Dihexa
10mg
$139
Potent HGF/c-Met activator derived from angiotensin IV that promotes synaptogenesis and has demonstrated cognitive enhancement millions of times more potent than BDNF in preclinical models.
- Tested by Freedom Diagnostics — independent US lab
- COA published with every lot
- Shipped from the US
For in-vitro research use only. Not for human or veterinary consumption, diagnostic, or therapeutic use.
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a small peptide derived from angiotensin IV, developed at Washington State University by Joseph Harding. It activates the HGF/c-Met signaling pathway to promote dendritic spine growth and synaptogenesis. In preclinical models it improved cognitive performance in Alzheimer's and scopolamine-impaired animals at doses millions of times lower than BDNF.
Dihexa binds hepatocyte growth factor (HGF) and potentiates its interaction with the c-Met receptor tyrosine kinase, activating downstream pathways (PI3K/Akt, MAPK/ERK) that drive synaptogenesis, dendritic arborization, and long-term potentiation. The c-Met pathway is critical for synaptic plasticity in the hippocampus and prefrontal cortex.
- Molecular Formula
- C₂₈H₄₅N₅O₅
- Molecular Weight
- 547.7 g/mol
- Form
- Lyophilized peptide powder
- Solubility
- Soluble in DMSO or ethanol; transdermal carrier recommended
- Dosage Range
- 1–3mg daily (research context)
- Plasma Half-Life
- ~3–4 hours
- Bioavailability
- High transdermal penetration
Certificate of analysis
Independent third-party report for the lot you receive — identity and purity. Available on request with your order; we'll email it back the same business day.
Cold-chain when required
Temperature-sensitive peptides ship with insulation and coolant. Store as indicated on the vial. Stability notes included with the order.
For research only
Sold for in-vitro research and laboratory use. Not for human or veterinary consumption. We don't advise on protocols or dosing.
- [01]
Dihexa: a small peptide with potent pro-cognitive properties
McCoy A.T. et al. · Journal of Pharmacology and Experimental Therapeutics · 2013
Dihexa reversed scopolamine-induced cognitive deficits and improved Morris water maze performance at nanogram doses, exceeding BDNF potency by seven orders of magnitude.
- [02]
HGF/c-Met signaling in synaptic plasticity and memory
Akimoto M. et al. · Neuropsychopharmacology · 2004
HGF/c-Met pathway activation enhanced dendritic spine density and LTP in hippocampal slices, supporting a role in memory consolidation.
- [03]
Angiotensin IV and cognitive function
Wright J.W. & Harding J.W. · Brain Research Reviews · 2004
AT4 receptor (c-Met) activation by angiotensin IV analogs consistently improved spatial memory and learning across multiple rodent models.
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