Overview
BPC-157 is a 15-amino acid peptide fragment derived from human gastric juice protein BPC. It has demonstrated remarkable healing properties across tendon, ligament, muscle, bone, and gut tissue in preclinical studies. It upregulates growth hormone receptor expression and promotes angiogenesis via VEGF, making it one of the most studied regenerative peptides in sports medicine research.
Mechanism of action
BPC-157 upregulates growth hormone receptors on tendon fibroblasts and stimulates VEGF-mediated angiogenesis to accelerate tissue vascularization. It modulates the nitric oxide system, increases expression of collagen synthesis genes, and counteracts NSAID/corticosteroid-induced inhibition of healing. In the gut it stabilizes the mucosal barrier and counteracts damage from endotoxins and inflammatory mediators.
Selected literature
- [01]
Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease
Sikiric P. et al. · Current Pharmaceutical Design · 2011
BPC-157 accelerated healing of colonic anastomosis and reduced inflammatory markers in multiple rodent models of IBD.
- [02]
BPC 157 and tendon healing
Chang C.H. et al. · Journal of Applied Physiology · 2011
BPC-157 significantly accelerated Achilles tendon healing and restored biomechanical strength faster than controls.
- [03]
Cytoprotective effect of BPC 157 on gastric mucosa
Sikiric P. et al. · Digestive Diseases and Sciences · 1993
BPC-157 protected gastric mucosa against various damaging agents and promoted ulcer healing in rat models.
The information on this page is summarized from the published research literature and is provided for reference and educational purposes only. It is not medical advice and should not be used to guide treatment decisions. Our peptides are sold for in-vitro research and laboratory use only.