GHK-Cu 100mg
Wellness
$119
Copper-binding tripeptide that activates over 4,000 genes involved in tissue regeneration, collagen synthesis, anti-inflammatory signaling, and wound healing.
Overview
GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring human plasma tripeptide that declines sharply with age — from ~200ng/mL at age 20 to ~80ng/mL by age 60. It acts as a potent tissue remodeling signal, activating genes involved in collagen/elastin synthesis, antioxidant defenses, and anti-inflammatory responses. Loren Pickart's pioneering research identified it as a master regulator of tissue repair.
Lab Results — 100mg
Every batch is independently tested. Results below are from the Certificate of Analysis for the 100mg batch.
Scientific Details
Molecular Formula
C₁₄H₂₃CuN₆O₄
Molecular Weight
403.9 g/mol
Form
Lyophilized copper peptide complex
Solubility
Freely soluble in water
Dosage Range
1–2mg/kg daily (research context)
Plasma Half-Life
~30–60 minutes (plasma)
Bioavailability
~90% subcutaneous
Resources
Key peer-reviewed studies supporting the efficacy and safety of this compound.
GHK-Cu and gene expression in skin remodeling
Pickart L. & Margolina A. — Biomolecules (2018)
Key FindingGHK-Cu reset gene expression patterns in aged skin fibroblasts toward a younger phenotype, upregulating 322 genes and downregulating 230.
Copper peptide GHK-Cu as a systemic wound healing agent
Pickart L. — Proceedings of the National Academy of Sciences (1973)
Key FindingGHK-Cu was isolated from human plasma as a potent stimulator of tissue regeneration and collagen synthesis in wound healing assays.
GHK tripeptide and anti-inflammatory activity
Canapp S.O. et al. — Wound Repair and Regeneration (2003)
Key FindingGHK-Cu significantly reduced inflammatory markers and accelerated wound closure in a controlled canine wound healing trial.