NAD+ 1,000mg
Wellness
$99
Nicotinamide adenine dinucleotide to replenish cellular NAD+ levels, support sirtuin activity, DNA repair, and mitochondrial energy metabolism.
Overview
NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme found in every cell, central to energy metabolism and over 500 enzymatic reactions. NAD+ levels decline by approximately 50% between ages 20 and 50. Replenishing NAD+ activates sirtuins (longevity-associated deacetylases), supports PARP-mediated DNA repair, and enhances mitochondrial biogenesis through PGC-1α activation.
Lab Results — 1,000mg
Every batch is independently tested. Results below are from the Certificate of Analysis for the 1,000mg batch.
Certificate of Analysis
Scientific Details
Molecular Formula
C₂₁H₂₇N₇O₁₄P₂
Molecular Weight
663.4 g/mol
Form
Lyophilized powder
Solubility
Freely soluble in water
Dosage Range
500–1,000mg daily
Plasma Half-Life
~1–2 hours (plasma NAD+)
Bioavailability
Variable; IV/subcutaneous preferred for systemic delivery
Resources
Key peer-reviewed studies supporting the efficacy and safety of this compound.
NAD+ metabolism and its roles in aging
Verdin E. — Science (2015)
Key FindingNAD+ decline with age impairs sirtuin and PARP activity; supplementation restored mitochondrial function and extended lifespan in model organisms.
Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication
Gomes A.P. et al. — Cell (2013)
Key FindingRaising NAD+ in aged mice restored mitochondrial homeostasis and reversed aspects of muscle aging within one week of treatment.
Nicotinamide adenine dinucleotide and sirtuins in aging and disease
Imai S. & Guarente L. — Trends in Cell Biology (2014)
Key FindingNAD+-sirtuin signaling axis regulates metabolic adaptation, stress resistance, and genomic stability across multiple tissue types.