SS-31 10mg
Longevity
$149
Szeto-Schiller peptide that targets the inner mitochondrial membrane to reduce oxidative stress, restore mitochondrial function, and support cellular energy production.
Overview
SS-31 (elamipretide) is a cell-permeable tetrapeptide that selectively concentrates in the inner mitochondrial membrane with 1,000-fold higher uptake than the cytoplasm. It binds to cardiolipin, a phospholipid critical for cristae structure and electron transport chain efficiency. Clinical trials have demonstrated improvements in heart failure, age-related muscle decline, and mitochondrial disease.
Lab Results — 10mg
Every batch is independently tested. Results below are from the Certificate of Analysis for the 10mg batch.
Certificate of Analysis
Scientific Details
Molecular Formula
C₃₂H₄₈N₈O₆
Molecular Weight
736.8 g/mol
Form
Lyophilized tetrapeptide powder
Solubility
Freely soluble in water
Dosage Range
0.1–0.25 mg/kg daily (research context)
Plasma Half-Life
~2–3 hours
Bioavailability
~85% subcutaneous
Resources
Key peer-reviewed studies supporting the efficacy and safety of this compound.
SS-31 reverses mitochondrial dysfunction and rescues diastolic function in heart failure
Chatfield K.C. et al. — JACC: Basic to Translational Science (2019)
Key FindingSS-31 restored mitochondrial cristae morphology and improved cardiac energetics in a large animal model of heart failure with preserved ejection fraction.
Elamipretide improves mitochondrial function in aged skeletal muscle
Siegel M.P. et al. — Aging Cell (2013)
Key FindingSS-31 treatment in aged mice improved mitochondrial ATP production, reduced ROS, and enhanced exercise capacity to levels approaching young animals.
Mitochondria-targeted peptide accelerates ATP recovery and reduces ROS generation
Szeto H.H. — Pharmacology & Experimental Therapeutics (2008)
Key FindingSS-31 concentrated 1,000-fold in the inner mitochondrial membrane and reduced oxidative damage by over 70% in ischemia-reperfusion injury models.